随访应做到早期发现局部复发和转移,以及发现第二处原发皮肤黑素瘤。因为高达8%的患者将发生第二处原发黑素瘤。[171]Titus-Ernstoff L, Perry AE, Spencer SK, et al. Multiple primary melanoma: two-year results from a population-based study. Arch Dermatol. 2006;142:433-438.http://www.ncbi.nlm.nih.gov/pubmed/16618861?tool=bestpractice.com[172]Ferrone CR, Ben Porat L, Panageas KS, et al. Clinicopathological features of and risk factors for multiple primary melanomas. JAMA. 2005;294:1647-1654.http://jamanetwork.com/journals/jama/fullarticle/201635http://www.ncbi.nlm.nih.gov/pubmed/16204664?tool=bestpractice.com
对于IA期患者,至少每年间断采集病史及体检一次,尤其要注意淋巴结。既往患有黑素瘤的高危患者后续应至专科门诊就诊,并行全身拍照及皮肤镜检查。[173]Salerni G, Terán T, Puig S, et al. Meta-analysis of digital dermoscopy follow-up of melanocytic skin lesions: a study on behalf of the International Dermoscopy Society. J Eur Acad Dermatol Venereol. 2013;27:805-814.http://www.ncbi.nlm.nih.gov/pubmed/23181611?tool=bestpractice.com任何新的或变化的、或者违反任何 ABCDE(病变的不对称、边界不规则、颜色变化、直径>6 mm、演变)规则的皮肤病损,应视为可疑,并应由皮肤科医生或经过培训的专业人员进行评估、或切除并进行组织学检查。
对于IB~III期的黑素瘤,应前3年每3~6个月进行一次完整的病史询问和体格检查,之后两年内每4~12个月检查一次,再之后每年一次。[174]Benvenuto-Andrade C, Oseitutu A, Agero AL, et al. Cutaneous melanoma: surveillance of patients for recurrence and new primary melanomas. Dermatol Ther. 2005;18:423-435.http://www.ncbi.nlm.nih.gov/pubmed/16297018?tool=bestpractice.com
对于黑素瘤患者常规随访仍然缺乏筛选、实验室和影像学检查方面的共识。以前一直提倡所有患者均应定期行胸部X片检查(CXR)和血清LDH。然而,这些检查对局限性黑素瘤的检出率极低,且假阳性率较高。[59]Wang TS, Johnson TM, Cascade PN, et al. Evaluation of staging chest radiographs and serum lactate dehydrogenase for localized melanoma. J Am Acad Dermatol. 2004;51:399-405.http://www.ncbi.nlm.nih.gov/pubmed/15337983?tool=bestpractice.com通常借助细针穿刺检查肿大的淋巴结及其他临床上可疑的团块。[175]Hall BJ, Schmidt RL, Sharma RR, et al. Fine-needle aspiration cytology for the diagnosis of metastatic melanoma: systematic review and meta-analysis. Am J Clin Pathol. 2013;140:635-642.http://www.ncbi.nlm.nih.gov/pubmed/24124141?tool=bestpractice.com