BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 六月 2019

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 上肢无力
  • 僵硬,伴随协调和平衡差
  • 痉挛状态,步态不稳

其他诊断因素

  • 跌倒倾向
  • 多涎和流涎
  • 不适当地爆发哭泣或发笑
  • 跌倒倾向

危险因素

  • 遗传倾向或家族史
  • 年龄>40 岁
  • 兵役
  • 职业性体育活动

诊断性检查

需要考虑的检查

  • 肌电图(EMG)
  • 反复神经刺激
  • 脑部和脊柱 MRI
  • 抗 GM1 抗体
全部具体信息

治疗流程

疾病持续状态

贡献者

Professor of Translational Neurology and Honorary Consultant Neurologist

University of Sheffield

Faculty of Medicine, Dentistry and Health

Department of Neuroscience

Sheffield Institute for Translational Neuroscience

Sheffield

UK

利益冲突披露
CJM has received fees for membership of data monitoring committees from Orion Pharma and Orphazyme.

Professor Christopher J. McDermott would like to gratefully acknowledge Dr Laura Simionescu and Dr Jeremy Shefner, previous contributors to this topic. LS and JS declare that they have no competing interests.

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Associate Professor of Neurology

Harvard Medical School

Boston

MA

利益冲突披露
DSW declares that he has no competing interests.

Associate Professor of Neurology

University of Pennsylvania

Philadelphia

PA

利益冲突披露
LM declares that he has no competing interests.

MRC/MNDA Lady Edith Wolfson Clinician Scientist & Honorary Consultant Neurologist

Oxford University Department of Clinical Neurology

John Radcliffe Hospital

Oxford

UK

利益冲突披露
MRT is a co-author of "Motor Neuron Disease – A Practical Manual" (Oxford University Press, 2010), which is a summary of his own understanding and practice, and which strongly influenced the recommendations for revision of the current article. He receives a proportion of royalties derived from sales of this book.

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