由于医院在预防 UTI 方面已有所改进,因此,HAP 和呼吸机相关性肺炎 (VAP) 是目前最常见(占总数的 22%)的院内感染。[3]Tablan OC, Anderson LJ, Besser R, et al. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep. 2004;53:1-36.http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5303a1.htmhttp://www.ncbi.nlm.nih.gov/pubmed/15048056?tool=bestpractice.com 重症监护病房中出现的 HAP 主要为 VAP。报告显示,每 1000 名住院患者中有 5 到 10 名患者发生 HAP。[4]Masterton RG, Galloway A, French G, et al. Guidelines for the management of hospital-acquired pneumonia in the UK: report of the working party on hospital-acquired pneumonia of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother. 2008;62:5-34.http://jac.oxfordjournals.org/content/62/1/5.fullhttp://www.ncbi.nlm.nih.gov/pubmed/18445577?tool=bestpractice.com 机械插管可导致患病率升高,在对重症监护病房患者开具的所有抗生素中,有一半用于治疗 HAP 或 VAP。[5]Richards MJ, Edwards JR, Culver DH, et al. Nosocomial infections in medical intensive care units in the United States: National Nosocomial Infections Surveillance System. Crit Care Med. 1999;27:887-892.http://www.ncbi.nlm.nih.gov/pubmed/10362409?tool=bestpractice.com HAP 可延长住院时间 7 到 11 天。[6]Muscedere JG, Day A, Heyland DK. Mortality, attributable mortality, and clinical events as end points for clinical trials of ventilator-associated pneumonia and hospital-acquired pneumonia. Clin Infect Dis. 2010;51(suppl 1):S120-S125.http://cid.oxfordjournals.org/content/51/Supplement_1/S120.longhttp://www.ncbi.nlm.nih.gov/pubmed/20597661?tool=bestpractice.com[7]Kollef MH, Hamilton CW, Ernst FR. Economic impact of ventilator-associated pneumonia in a large matched cohort. Infect Control Hosp Epidemiol. 2012;33:250-256.http://www.ncbi.nlm.nih.gov/pubmed/22314062?tool=bestpractice.com 住院后 5 天内诊断出的病例大多由敏感细菌引起(除非在过去 90 天内患者暴露于抗生素)。[8]American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.http://www.atsjournals.org/doi/full/10.1164/rccm.200405-644ST#.UkWJW9KsjTohttp://www.ncbi.nlm.nih.gov/pubmed/15699079?tool=bestpractice.com 住院 5 天后被诊断出 HAP 的患者,其肺炎通常由耐药菌引起。[8]American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.http://www.atsjournals.org/doi/full/10.1164/rccm.200405-644ST#.UkWJW9KsjTohttp://www.ncbi.nlm.nih.gov/pubmed/15699079?tool=bestpractice.com HAP 的粗死亡率可能高达 30% 至 70%,但许多患者是死于基础疾病,而不是 HAP 本身。[8]American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.http://www.atsjournals.org/doi/full/10.1164/rccm.200405-644ST#.UkWJW9KsjTohttp://www.ncbi.nlm.nih.gov/pubmed/15699079?tool=bestpractice.com 归因死亡率约为 10%。[9]Melsen WG, Rovers MM, Koeman M, et al. Estimating the attributable mortality of ventilator-associated pneumonia from randomized prevention studies. Crit Care Med. 2011;39:2736-2742.http://www.ncbi.nlm.nih.gov/pubmed/21765351?tool=bestpractice.com 死亡率增加与菌血症有关,特别是由不动杆菌或假单胞菌引起的菌血症。[8]American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.http://www.atsjournals.org/doi/full/10.1164/rccm.200405-644ST#.UkWJW9KsjTohttp://www.ncbi.nlm.nih.gov/pubmed/15699079?tool=bestpractice.com[10]Heyland DK, Cook DJ, Griffith L, et al. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am J Respir Crit Care Med. 1999;159:1249-1256.http://www.atsjournals.org/doi/full/10.1164/ajrccm.159.4.9807050#.UkWV5tKsjTohttp://www.ncbi.nlm.nih.gov/pubmed/10194173?tool=bestpractice.com 该死亡率还与内科疾病(非外科疾病)以及无效的经验性抗菌治疗相关。[10]Heyland DK, Cook DJ, Griffith L, et al. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am J Respir Crit Care Med. 1999;159:1249-1256.http://www.atsjournals.org/doi/full/10.1164/ajrccm.159.4.9807050#.UkWV5tKsjTohttp://www.ncbi.nlm.nih.gov/pubmed/10194173?tool=bestpractice.com 约 10% 到 20% 的烧伤患者有吸入性损伤,这会诱发 VAP。[11]Mosier MJ, Pham TN. American Burn Association practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia (VAP) in burn patients. J Burn Care Res. 2009;30:910-928.http://www.ncbi.nlm.nih.gov/pubmed/19826271?tool=bestpractice.com