BMJ Best Practice
最后审核时间： 七月 2019
最近更新时间： 七月 2019

小结

定义

病史和查体

关键诊断因素

  • 性格、社会行为与习惯粗化
  • 言语流畅性或理解能力进行性丧失
  • 记忆损伤、定向障碍及失用症的产生
  • 进行性自我忽视及抛弃工作、活动与社会接触
全部具体信息

其他诊断因素

  • 发病年龄的高峰为50-60岁中期
  • FTD家族史
  • 进食习惯改变
  • 注意迟钝、不能全神贯注、努力不足及冲动反应
全部具体信息

危险因素

  • MAPT基因突变
  • PGRN基因突变
  • 头部外伤
  • 甲状腺疾病
全部具体信息

诊断性检查

首要检查

  • 正式认知测试
  • 脑部 MRI
  • 脑部 CT
  • 全血细胞计数 (FBC）
全部具体信息

需要考虑的检查

  • 脑部SPECT
  • 脑 18F-脱氧葡萄糖 (FDG) PET
  • 脑活组织检查
全部具体信息

新兴检查

  • 基因检测
  • 脑脊液分析
全部具体信息

治疗流程

急性

所有患者

疾病持续状态

临终护理

贡献者

作者 查看所有

Consultant Psycho-geriatrician

Waitemata District Health Board

Auckland

New Zealand

利益冲突披露
RKR worked for BMJ Clinical Evidence in 2012 and received honorarium. RKR declares that he has no other competing interests.

Consultant Psycho-geriatrician

Waitemata District Health Board

Honorary Senior Lecturer in Old Age Psychiatry

University of Auckland

Auckland

New Zealand

利益冲突披露
SJ declares that he has no competing interests.

Dr Raghava Kurup Radhakrishnan and Dr Sachin Jauhari would like to gratefully acknowledge Dr Lawrence Whalley and Dr Chiadi Onyike, the previous contributors to this topic. LW and CO declare that they have no competing interests.

同行评议专家 查看所有

Director

Memory Disorders Program

Department of Neurology

University of North Carolina at Chapel Hill

NC

利益冲突披露
DK has received research support, speaking honoraria, and consulting fees from Eisai, Forest Laboratories, Johnson & Johnson, Medivation, Novartis, Ortho-McNeil, and Pfizer.

Professor of Neurology

University of California

San Francisco

CA

利益冲突披露
BLM declares that he has no competing interests.

Professor of Neurology

Department of Neurology/Alzheimer Center

VU University Medical Center

Amsterdam

The Netherlands

利益冲突披露
PS declares that he has no competing interests.

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