不同类型 FTD 的疾病进展不尽相同。 行为变异型患者的进展迅速，而语义性痴呆患者的进展缓慢。[38]Mioshi E, Hsieh S, Savage S, et al. Clinical staging and disease progression in frontotemporal dementia. Neurology. 2010 May 18;74(20):1591-7.http://www.ncbi.nlm.nih.gov/pubmed/20479357?tool=bestpractice.com 诊断确认后存活期（中数）为80个月，[67]Xie SX, Forman MS, Farmer J, et al. Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):126-9.http://www.ncbi.nlm.nih.gov/pubmed/17615171?tool=bestpractice.com 但也有缓慢进展病例的相关报道。[68]Kipps CM, Nestor PJ, Fryer TD, et al. Behavioural variant frontotemporal dementia: not all it seems? Neurocase. 2007 Aug;13(4):237-47.http://www.ncbi.nlm.nih.gov/pubmed/17852756?tool=bestpractice.com 对于伴有震颤麻痹及伴有运动神经元疾病的患者，存活时间可能更短，[69]Pasquier F, Richard F, Lebert F. Natural history of frontotemporal dementia: comparison with Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17(4):253-7.http://www.ncbi.nlm.nih.gov/pubmed/15178930?tool=bestpractice.com 猝死可能常见。[69]Pasquier F, Richard F, Lebert F. Natural history of frontotemporal dementia: comparison with Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17(4):253-7.http://www.ncbi.nlm.nih.gov/pubmed/15178930?tool=bestpractice.com 与阿尔茨海默病患者相比，FTD 患者的生存期更短，认知和功能下降更快。[70]Rascovsky K, Salmon DP, Lipton AM, et al. Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology. 2005 Aug 9;65(3):397-403.http://www.ncbi.nlm.nih.gov/pubmed/16087904?tool=bestpractice.com 有研究证实，早期开展正式的痴呆照护可能能够改善患者的生存情况，[69]Pasquier F, Richard F, Lebert F. Natural history of frontotemporal dementia: comparison with Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17(4):253-7.http://www.ncbi.nlm.nih.gov/pubmed/15178930?tool=bestpractice.com 但此项观察性结果尚未被验证过。药物干预措施也被证实可以改善患者的生存情况。
