幼儿的生长激素(GH)水平
使用生长激素 (GH)对幼儿进行治疗还有待于调查。[35]Davenport ML, Crowe BJ, Travers SH, et al. Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial. J Clin Endocrinol Metab. 2007;92:3406-3416.http://jcem.endojournals.org/content/92/9/3406.fullhttp://www.ncbi.nlm.nih.gov/pubmed/17595258?tool=bestpractice.com
给予年轻女孩低剂量的雌激素
有人建议用极低剂量的雌激素模仿正常的发育模式对年轻的女孩进行治疗,尽管需要更多的研究。[36]Davenport ML. Moving toward an understanding of hormone replacement therapy in adolescent girls. Ann N Y Acad Sci. 2008;1135:126-137.http://www.ncbi.nlm.nih.gov/pubmed/18574218?tool=bestpractice.com[37]Ross JL, Quigley CA, Cao D, et al. Growth hormone plus childhood low-dose estrogen in Turner's syndrome. N Engl J Med. 2011;364:1230-1242.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083123/http://www.ncbi.nlm.nih.gov/pubmed/21449786?tool=bestpractice.com
β 受体阻滞剂或血管紧张素 II 受体拮抗剂
利用β受体阻滞剂或血管紧张素 II 受体拮抗剂治疗患有已知先天性心血管疾病(如二叶型主动脉瓣、主动脉缩窄、或主动脉根部扩张)的患者以降低并发症的风险尚在讨论中但还未得到证实。[3]Bondy CA; Turner Syndrome Consensus Study Group. Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab. 2007;92:10-25.http://press.endocrine.org/doi/full/10.1210/jc.2006-1374http://www.ncbi.nlm.nih.gov/pubmed/17047017?tool=bestpractice.com
雄激素补充
正常人的卵巢在育龄期将分泌大量的睾丸激素,而补充雌激素和雄激素已被建议用于卵巢切除后或过早绝经的女性。一项研究表明,将睾酮加入到特纳综合征成人的雌激素治疗可改善肥瘦质量比并提高认知功能的各个方面以及生活质量。[38]Zuckerman-Levin N, Frolova-Bishara T, Militianu D, et al. Androgen replacement therapy in Turner syndrome: a pilot study. J Clin Endocrinol Metab. 2009;94:4820-4827.http://www.ncbi.nlm.nih.gov/pubmed/19846743?tool=bestpractice.com进一步的研究将确定在安全得以确保的前提下这一额外激素治疗的作用。