HS 可见于所有人群,但最常见于北欧裔人群。该人群的患病率为 1/5000。[5]Bolton-Maggs PH, Langer JC, Iolascon A, et al; General Haematology Task Force of the British Committee for Standards in Haematology. Guidelines for the diagnosis and management of hereditary spherocytosis - 2011 update. Br J Haematol. 2012;156:37-49.http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2011.08921.x/fullhttp://www.ncbi.nlm.nih.gov/pubmed/22055020?tool=bestpractice.com 献血者筛查表明,轻度形式可能更为常见(患病率高达 1/800)。[12]Kutter D. Hereditary spherocytosis is more frequent than expected: what to tell the patient? Bull Soc Sci Med Grand Duche Luxemb. 2005:7-22.http://www.ncbi.nlm.nih.gov/pubmed/16042049?tool=bestpractice.com 这些非常轻的类型没有临床意义的可能性较大。仅在黑人中罕见描述 HS。它可发生在任何性别的人群中,并且可在任何年龄出现,部分取决于临床严重程度。