建议
英国国家卫生与临床优化研究所(NICE)和加拿大预防医疗工作组均提倡在初级医疗卫生机构对抑郁进行筛查。[55]National Institute for Health and Care Excellence. Depression in adults: recognition and management. April 2018 [internet publication].https://www.nice.org.uk/guidance/CG90
美国预防服务工作组发现了在一般成年人群(包括妊娠和产后女性)中推荐进行抑郁筛查令人信服的证据,[56]Siu AL; US Preventive Services Task Force (USPSTF), Bibbins-Domingo K, et al. Screening for depression in adults: US Preventive Services Task Force recommendation statement. JAMA. 2016 Jan 26;315(4):380-7.https://jamanetwork.com/journals/jama/fullarticle/2484345http://www.ncbi.nlm.nih.gov/pubmed/26813211?tool=bestpractice.com 但在某些国家(例如加拿大)的公共卫生机构中则不推荐进行常规筛查。 [57]Canadian Task Force on Preventive Health Care; Joffres M, Jaramillo A, Dickinson J, et al. Recommendations on screening for depression in adults. CMAJ. 2013 Jun 11;185(9):775-82.http://www.cmaj.ca/content/suppl/2013/07/29/cmaj.130403.DC3/depress-update.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/23670157?tool=bestpractice.com筛查后,系统应当确保进行准确诊断、有效治疗和适当随访。
工具
目前常用的筛查和诊断工具均基于 DSM-IV 标准。基于 DSM-5 的工具目前仍未广泛使用;然而,从 DSM-IV 到 DSM-5,症状及诊断标准并没有大的变化,因此预计筛查工具也并不会发生显著的改变。
患者健康问卷-2 (PHQ-2) 源自 “精神疾病的初级医疗评估“(PRIME-MD)工具,能够快速、准确的仅用两个问题筛查抑郁:[40]Mitchell AJ, Yadegarfar M, Gill J, et al. Case finding and screening clinical utility of the Patient Health Questionnaire (PHQ-9 and PHQ-2) for depression in primary care: a diagnostic meta-analysis of 40 studies. BJPsych Open. 2016 Mar 9;2(2):127-38.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995584/http://www.ncbi.nlm.nih.gov/pubmed/27703765?tool=bestpractice.com
“在过去 2 周内,您有没有感到情绪低落、压抑、没有希望?”
“在过去 2 周内,您有没有对做事失去兴趣,或无法感到愉快?”
以上两问中任何一问为肯定的回答就需要进行完整的 DSM-IV-TR 标准的评估或者使用相应的工具。
可将患者健康问卷-9 (PHQ-9) 用作诊断和疾病管理工具。PHQ-9 包含 9 个问题,是一种反映 DSM-IV-TR 标准的抑郁问卷。它将目前症状分为 0(无症状)到 3(每日有症状)。该工具已获准在初级医疗机构中应用。在治疗期间重复使用 PHQ-9 可以帮助临床医生客观监测治疗反应。
筛查妊娠和产后女性
证据表明筛查妊娠和产后女性可降低抑郁风险。[3]O'Connor E, Rossom RC, Henninger M, et al. Primary care screening for and treatment of depression in pregnant and postpartum women: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2016 Jan 26;315(4):388-406.http://www.ncbi.nlm.nih.gov/pubmed/26813212?tool=bestpractice.com[4]Institute for Clinical Systems Improvement. Depression, adult in primary care. March 2016 [internet publication].https://www.icsi.org/guidelines__more/catalog_guidelines_and_more/catalog_guidelines/catalog_behavioral_health_guidelines/depression/[56]Siu AL; US Preventive Services Task Force (USPSTF), Bibbins-Domingo K, et al. Screening for depression in adults: US Preventive Services Task Force recommendation statement. JAMA. 2016 Jan 26;315(4):380-7.https://jamanetwork.com/journals/jama/fullarticle/2484345http://www.ncbi.nlm.nih.gov/pubmed/26813211?tool=bestpractice.com 临床医生可在产后 4-6 周时使用爱丁堡产后抑郁量表来筛查产后抑郁。Edinburgh Postnatal Depression Scale 此量表针对产后女性,共有 10 个问题,总分≥10 分提示抑郁。[41]Di Florio A, Putnam K, Altemus M, et al. The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale. Psychol Med. 2017 Apr;47(5):787-99. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369767/http://www.ncbi.nlm.nih.gov/pubmed/27866476?tool=bestpractice.com[42]Wisner KL, Parry BL, Piontek CM. Clinical practice. Postpartum depression. N Engl J Med. 2002 Jul 18;347(3):194-9.http://www.ncbi.nlm.nih.gov/pubmed/12124409?tool=bestpractice.com[43]Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry. 1987 Jun;150:782-6.http://www.ncbi.nlm.nih.gov/pubmed/3651732?tool=bestpractice.com 尽管它并不评估抑郁的严重程度,但对自杀观念进行了评估。