BMJ Best Practice
最后审核时间: 十月 2018
最近更新时间: 四月 2018

小结

定义

病史和查体

关键诊断因素

  • 异基因造血干细胞移植(haematopoietic cell transplantation, HCT)受者
  • 无血缘供者
  • 经产女性供者
  • 弥漫性斑状丘疹伴发热

其他诊断因素

  • 造血干细胞移植 14 天后
  • 环磷酰胺 + 全身放射治疗(Cy/TBI)预处理方案
  • 外周血干细胞作为移植物来源
  • GVHD 预防不足

危险因素

  • 人类白细胞抗原不同
  • 老年组受者或供者
  • 女性供者和男性受者
  • 经产女性供者

诊断性检查

首要检查

  • 全血细胞计数(FBC)
  • 血清电解质
  • 肝功能检查
  • 尿液分析
全部具体信息

需要考虑的检查

  • 腹部 CT
  • 肝脏多普勒超声检查
  • 组织活检(皮肤、肝脏、胃肠道、口腔病变或肺部)
  • 肺功能检查 (pulmonary function test, PFT)
全部具体信息

治疗流程

贡献者

Sung Choi MD, MS

Assistant Professor

Department of Pediatrics and Communicable Diseases

Division of Pediatric Hematology Oncology/Blood and Marrow Transplantation

University of Michigan

Ann Arbor

MI

利益冲突披露
SC is an author of a number of references cited in this monograph.
Lyndsey Runaas MD

Fellow, Hematology and Oncology

Division of Hematology/Oncology

University of Michigan

Ann Arbor

MI

利益冲突披露
LR declares that she has no competing interests.

Dr Sung Choi and Dr Lyndsey Runaas would like to gratefully acknowledge Dr Pavan Reddy, a previous contributor to this monograph. PR is an author of a number of references cited in this monograph.

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Associate Professor of Medicine

Harvard Medical School

Dana-Farber Cancer Institute

Boston

MA

利益冲突披露
CC declares that he has no competing interests.

Senior Lecturer

Institute of Child Health

Consultant in Paediatric Immunology & Bone Marrow Transplantation

Great Ormond Street Hospital

London

UK

利益冲突披露
WQ declares that he has no competing interests.

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